A Strategy of "Random Glycosylation" for the Production of Oligosaccharide Libraries

A Strategy of "Random Glycosylation" for the Production of Oligosaccharide Libraries

Six at one blow! The creation of small oligosaccharide libraries was achieved by a new strategy of random glycosylation of nonprotected sugars. With tri‐O‐benzyl‐L‐fucopyranosyl trichloroacetimidate as donor and βGal(1 → n)βGlcNAcOR (n = 3, 4, 6; R = (CH2)8OC6H4‐p‐OMe) as acceptors, all six trisacc...

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Veröffentlicht in:Angewandte Chemie International Edition 1996-01, Vol.34 (23-24), p.2720-2722
Hauptverfasser: Kanie, Osamu, Barresi, Frank, Ding, Yili, Labbe, Jill, Otter, Albin, Forsberg, L. Scott, Ernst, Beat, Hindsgaul, Ole
Format: Artikel
Sprache:eng
Schlagworte:
combinatorial chemistry
glycosylations
oligosaccharides
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Zusammenfassung:Six at one blow! The creation of small oligosaccharide libraries was achieved by a new strategy of random glycosylation of nonprotected sugars. With tri‐O‐benzyl‐L‐fucopyranosyl trichloroacetimidate as donor and βGal(1 → n)βGlcNAcOR (n = 3, 4, 6; R = (CH2)8OC6H4‐p‐OMe) as acceptors, all six trisaccharides form in DMF in roughly equal quantities. It is astounding that all free OH groups are fucosylated at a similar rate.
ISSN:0570-0833
1521-3773
DOI:10.1002/anie.199527201