Burial of Hydrocarbon Causes Cooperative Enhancement of Electrostatic Binding

Burial of Hydrocarbon Causes Cooperative Enhancement of Electrostatic Binding

The introduction of alanine methyl groups in adjacent positions on a peptide ligand results in a cooperative enhancement of electrostatic binding from the burial of hydrocarbon. This observation may explain why larger changes in free energy occur when hydrocarbon substituents are buried in a molecul...

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Veröffentlicht in:Angewandte Chemie International Edition 1995-07, Vol.34 (13-14), p.1483-1485
Hauptverfasser: Sharman, Gary J., Searle, Mark S., Benhamu, Bellinda, Groves, Patrick, Williams, Dudley H.
Format: Artikel
Sprache:eng
Schlagworte:
electrostatic binding
hydrophobic effect
molecular recognition
peptides
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Zusammenfassung:The introduction of alanine methyl groups in adjacent positions on a peptide ligand results in a cooperative enhancement of electrostatic binding from the burial of hydrocarbon. This observation may explain why larger changes in free energy occur when hydrocarbon substituents are buried in a molecular recognition site than can be accounted for by the solvent transfer model (classical hydrophobic effect).
ISSN:0570-0833
1521-3773
DOI:10.1002/anie.199514831