Ring Closures on Polymeric Supports-Formation of Extremely Large Macrocycles by Intrapolymeric Cyclooligomerizations

Extremely large rings with up to several hundred ring atoms are obtained by cyclooligomerization of polymer‐bound linear molecules, for example cyclic oligoamides of ϵ‐aminohexanoic acid with up to 280 ring atoms. Thus weakly crosslinked polymeric supports do not enforce steric isolation of covalently bound bifunctional molecules, as previously reported. Instead intrapolymer reactions with subsequent ring closure dominate.