Salting Out Selective Extraction-A Novel Method for the Optical Resolution of Chiral Sulfinylcarboxylic Acids and Its Application for the Convenient Determination of Optical Purity

Salting Out Selective Extraction-A Novel Method for the Optical Resolution of Chiral Sulfinylcarboxylic Acids and Its Application for the Convenient Determination of Optical Purity

When fractional recrystallization fails to separate diastereomeric salts, the enantiomers may still be resolved by the selective extraction of the diastereomeric salts. Racemic sulfinylcarboxylic acids were treated with cinchona bark alkaloids and NaOH (or KHCO3). Repeated extractions led to high en...

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Veröffentlicht in:Angewandte Chemie (International ed.) 1992-12, Vol.31 (12), p.1631-1633
1. Verfasser: RABAI, J
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Exact sciences and technology
Organic chemistry
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Zusammenfassung:When fractional recrystallization fails to separate diastereomeric salts, the enantiomers may still be resolved by the selective extraction of the diastereomeric salts. Racemic sulfinylcarboxylic acids were treated with cinchona bark alkaloids and NaOH (or KHCO3). Repeated extractions led to high enantiomeric excesses.
ISSN:0570-0833
1521-3773
DOI:10.1002/anie.199216311