Enantioselective Synthesis of D-threo-β-Hydroxy-α-amino Acids with Titanium-Carbohydrate Complexes

Enantioselective Synthesis of D-threo-β-Hydroxy-α-amino Acids with Titanium-Carbohydrate Complexes

The addition of the glycine enolate to aldehydes to give the title compounds 2 proceeds with high enantioselectivity and diastereoselectivity, when the titanate 1 is used as chiral template and reagent (R*, see the two preceding communications). Amino acid esters with free or protected amino groups...

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Veröffentlicht in:Angewandte Chemie International Edition 1989-04, Vol.28 (4), p.497-498
Hauptverfasser: Bold, Guido, Duthaler, Rudolf O., Riediker, Martin
Format: Artikel
Sprache:eng
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Zusammenfassung:The addition of the glycine enolate to aldehydes to give the title compounds 2 proceeds with high enantioselectivity and diastereoselectivity, when the titanate 1 is used as chiral template and reagent (R*, see the two preceding communications). Amino acid esters with free or protected amino groups are readily accessible.
ISSN:0570-0833
1521-3773
DOI:10.1002/anie.198904971