Total Synthesis of the Antitumor Antibiotic WF-3161
The cyclopeptide WF‐3161 (2) counts among the most effective cytostatics in vitro.—After stereoselective synthesis of the linear Z‐tetrapeptide pentafluorophenyl ester 1, the ring is subsequently closed (in 74% yield) by catalytic hydrogenation. Conversion of the chloroketal into an epoxyketone comp...
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| Veröffentlicht in: | Angewandte Chemie International Edition 1989-03, Vol.28 (3), p.333-334 |
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| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | The cyclopeptide WF‐3161 (2) counts among the most effective cytostatics in vitro.—After stereoselective synthesis of the linear Z‐tetrapeptide pentafluorophenyl ester 1, the ring is subsequently closed (in 74% yield) by catalytic hydrogenation. Conversion of the chloroketal into an epoxyketone completes the synthesis of the natural product. |
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| ISSN: | 0570-0833 1521-3773 |
| DOI: | 10.1002/anie.198903331 |