2D NMR Trace Analysis by Continuous Hyperpolarization at High Magnetic Field

Nuclear magnetic resonance is often the technique of choice in chemical analysis because of its sensitivity to molecular structure, quantitative character, and straightforward sample preparation. However, determination of trace analytes in complex mixtures is generally limited by low sensitivity and extensive signal overlap. Here, we present an approach for continuous hyperpolarization at high magnetic field that is based on signal amplification by reversible exchange (SABRE) and can be straightforwardly incorporated in multidimensional NMR experiments. This method was implemented in a 2D correlation experiment that allows detection and quantification of analytes at nanomolar concentration in complex solutions. NMR‐Spurenanalyse: Kontinuierliche Hyperpolarisierung wurde verwendet, um verdünnte Analyten über ihre 2D‐NMR‐Korrelationen mit von para‐H2 abgeleiteten Hydriden zu untersuchen (siehe Bild). Die Kombination der 2D‐NMR‐Resonanzdispersion mit der durch para‐H2 induzierten Signalverstärkung ermöglichte die Detektion und Quantifizierung von nanomolaren Konzentration in komplexen Mischungen.