A Scalable Engineered Extracellular Matrix Platform to Expand Tumor Cells

Cell Therapies In article number 2300012, Joerg Lahann and co‐workers present a scalable three‐dimensional engineered extracellular matrix (3D EECM) as a novel cell expansion platform for personalized cancer immunotherapies. By integrating shear‐induced fibronectin fibers into 3D polycaprolactone scaffolds, efficient expansion of cancer cells can be achieved, making it a potential solution for obtaining a clinically relevant number of cells necessary for personalized cancer treatment. The cover image shows the scaffolds (brown) featuring engineered extracellular matrix with a fibrillar architecture (green) to promote three‐dimensional expansion of human cancer cells (blue).