Effect of Age Range on Power for a Clinical Trial Investigating the Effect of Intensive Systolic Blood Pressure Control on White Matter Hyperintensity Volume Accumulation

Effect of Age Range on Power for a Clinical Trial Investigating the Effect of Intensive Systolic Blood Pressure Control on White Matter Hyperintensity Volume Accumulation

Background Epidemiological evidence has repeatedly demonstrated elevated systolic blood pressure (SBP) in midlife as a modifiable risk factor for Alzheimer’s Disease and Related Dementia (ADRD) later in life. Despite SBP being readily treatable with safe and inexpensive medications, no clinical inte...

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Veröffentlicht in:Alzheimer's & dementia 2023-12, Vol.19 (S10), p.n/a
Hauptverfasser: Pruzin, Jeremy J., Chen, Yinghua, Chen, Kewei, Koijs, Daniel, Newby, Danielle, Winchester, Laura M, Thomas, Ronald G., McGrath, Emer R, Su, Yi, Reboussin, David M., Pajewski, Nicholas M., Beiser, Alexa S., Seshadri, Sudha, Tariot, Pierre N.
Format: Artikel
Sprache:eng
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Zusammenfassung:Background Epidemiological evidence has repeatedly demonstrated elevated systolic blood pressure (SBP) in midlife as a modifiable risk factor for Alzheimer’s Disease and Related Dementia (ADRD) later in life. Despite SBP being readily treatable with safe and inexpensive medications, no clinical intervention implementing a lower SBP goal (
ISSN:1552-5260
1552-5279
DOI:10.1002/alz.081985