Comparative pathological study of Carbon‐11 labeled Pittsburgh compound‐B PET Centiloid Scale and amyloid beta deposition in postmortem brains

Background Centiloid Scale (CL) was developed to standardize the quantitative results of amyloid beta (Aβ) positron emission tomography (PET). CL can allow not only categorization of the binary results of amyloid PET as positive or negative, but also parametric weighting within each category. To date, several neuropathological studies evaluated the performance of CL, but further validation studies of the Asian population, elderly cohorts, and relatively short intervals between PET scanning and autopsy may be required. Method Twenty‐two consecutive autopsy cases registered to the Brain Bank for Aging Research, who received Carbon‐11 labeled Pittsburgh compound‐B PET were included. Amyloid PET results of CL were compared with the final neuropathological diagnosis and the grading of Aβ deposition. Result The mean age of the 22 patients at death was 81.0 (SD: 8.4) years, seven of whom fulfilled pathological diagnosis of Alzheimer’s disease (AD). The mean interval from PET to autopsy was 17.5 (SD: 15.3) months. The mean CL was higher in the AD group (88.5 [SD: 30.9]) than in the non‐AD group (9.7 [SD: 25.6], p