A short computerized cognitive training may affect cortical sources of rsEEG rhythms in Alzheimer’s disease patients

Background Previous evidence showed abnormal posterior sources of resting‐state electroencephalographic (rsEEG) delta (0.05) was observed in the rsEEG markers after the CCT program. In PD patients, the widespread delta source activities significantly decreased after cognitive training. Conclusion These preliminary results suggest that the CCT program with this application of serious games differently affects the cortical neural synchronization mechanisms of rsEEG of the AD and PD patients. In the AD patients, it may have no effect, possibly because of the severely compromised integrity of the cholinergic system in those patients.