"Multi‐domain interventions for dementia prevention – A Systematic Review"

Background The increase in the ageing population is accompanied by increased rates of cognitive decline and dementia, which has a profound impact on both morbidity and mortality and a significant care‐related stress and financial burden. In the new global economy, dementia has become a central issue for public health in Australia. Dementia is the second greatest cause of death in Australia and about 60% of all dementia cases are due to Alzheimer’s disease (AD). In AD, damage starts occurring in the brain 20 to 30 years prior to any cognitive symptom. There is currently no cure for AD. However, the year between the start of its development and the appearance of symptoms represent a window of opportunity for implementing strategies to delay or prevent the progression of the disease through lifestyle interventions. Method The study will be conduct in two parts: 1) A systematic review based on multidomain interventions. 2) AU ARROW Intervention. A comprehensive search of electronic databases (EMBASE, MEDLINE, CINAHL, Cochrane, and Scopus) will be performed to retrieve publications and alerts were set to identify publications until 31 august 2021. Results An expected positive outcome would give more evidence that lifestyle changes and if a single nutrient itself or a whole pattern as MIND DIET that are relatively easy to adopt, can help to prevent or delay brain function decline and dementia, such as Alzheimer’s disease dementia in an Australian population Conclusion a multidomain intervention focused on cognitive training, and nutritional and physical activity counselling seems decrease cognitive decline in older adults.