An Expeditious Approach for the Synthesis of β‐Carboline−Pyrazole‐Based Molecular Hybrids

A simple and highly efficient one‐pot, metal‐free approach has been developed for the synthesis of β‐carboline−pyrazole/−pyrazoline‐based molecular hybrids. The synthesis of C1‐tethered β‐carboline−(N‐acetyl)pyrazolines was achieved by using a cyclocondensation approach, whilst β‐carboline‐substituted pyrazoles were synthesized through an I2‐mediated oxidative condensation reaction. This procedure provides easy access to biologically interesting di‐ and trisubstituted pyrazoles that are decorated with β‐carboline frameworks. Hybrid theory: A metal‐free cyclocondensation approach has been developed for the synthesis of β‐carboline−pyrazole‐ and β‐carboline−pyrazoline‐based molecular hybrids.