Rh III ‐Catalyzed Directed C−H Bromination and Iodination to Synthesize Atropisomeric Biaryls
The [Rh III Cp*]‐catalyzed directed C−H bromination and iodination reactions of 2‐aryl isoquinolines/pyridines are highly efficient and afford atropisomeric biaryl compounds (Cp*=1,2,3,4,5‐pentamethylcyclopenta‐2,4‐dienyl) in good yields. Among several reported C−H bond halogenation methods, the com...
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| Veröffentlicht in: | Asian journal of organic chemistry 2016-09, Vol.5 (9), p.1107-1110 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | The [Rh
III
Cp*]‐catalyzed directed C−H bromination and iodination reactions of 2‐aryl isoquinolines/pyridines are highly efficient and afford atropisomeric biaryl compounds (Cp*=1,2,3,4,5‐pentamethylcyclopenta‐2,4‐dienyl) in good yields. Among several reported C−H bond halogenation methods, the combination of [Rh
III
Cp*Cl
2
]
2
/AgSbF
6
,
N
‐halosuccinimide, and pivalic acid in 1,2‐dichloroethane is found to be the only effective catalytic system to provide atropisomeric 2′‐halogenated 2‐aryl isoquinolines/pyridines. |
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| ISSN: | 2193-5807 2193-5815 |
| DOI: | 10.1002/ajoc.201600259 |