Fluorescent Angiotensin AT 1 Receptor Antagonists
Fluorescent selective angiotensin AT 1 receptor antagonists (sartans) that contain naphthalene ( 6 , 7 , 10 , and 11 ), anthracene ( 12 and 14 ), acenaphthene ( 13 and 15 ), and coumarin ( 8 and 9 ) substituents have been prepared and their preliminary pharmacology evaluated in Chinese hamster ovary...
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| Veröffentlicht in: | Asian journal of organic chemistry 2012-11, Vol.1 (3), p.274-279 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Fluorescent selective angiotensin AT
1
receptor antagonists (sartans) that contain naphthalene (
6
,
7
,
10
, and
11
), anthracene (
12
and
14
), acenaphthene (
13
and
15
), and coumarin (
8
and
9
) substituents have been prepared and their preliminary pharmacology evaluated in Chinese hamster ovary (CHO) cell based assays. Compounds
6
–
15
proved to be effective sartans with p
K
B
estimates in the range of 6.7–10.5; their potential as cellular imaging agents is also discussed. |
|---|---|
| ISSN: | 2193-5807 2193-5815 |
| DOI: | 10.1002/ajoc.201200064 |