Association of apolipoprotein E allele ϵ4 with late-onset sporadic Alzheimer's disease

Association of apolipoprotein E allele ϵ4 with late-onset sporadic Alzheimer's disease

Apolipoprotein E, type ϵ4 allele (ApoE ϵ4), is associated with late‐onset sporadic Alzheimer's disease (AD) in French patients. The association is highly significant (0.45 AD versus 0.12 controls forϵ4 allele frequencies). These data support the involvement of ApoEϵ4 allele as a very important...

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Veröffentlicht in:American journal of medical genetics 1994-09, Vol.54 (3), p.286-288
Hauptverfasser: Lucotte, G., Visvikis, S., Leininger-Möler, B., David, F., Berriche, S., Revéilleau, S., Couderc, R., Babron, M. C., Aguillon, D., Siest, G.
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer's disease
apolipoprotein E
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
lateonset and sporadic forms
Medical sciences
Neurology
risk factor
ϵ4 allele
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Zusammenfassung:Apolipoprotein E, type ϵ4 allele (ApoE ϵ4), is associated with late‐onset sporadic Alzheimer's disease (AD) in French patients. The association is highly significant (0.45 AD versus 0.12 controls forϵ4 allele frequencies). These data support the involvement of ApoEϵ4 allele as a very important risk factor for the clinical expression of AD. © 1994 Wiley‐Liss, Inc.
ISSN:0148-7299
1096-8628
DOI:10.1002/ajmg.1320540319