Heparin‐induced thrombocytopenia and fatal thrombosis in a patient with activated protein C resistance

Heparin‐induced thrombocytopenia and fatal thrombosis in a patient with activated protein C resistance

We report a 20‐year‐old woman who developed heparin‐induced thrombocytopenia (HIT) associated with devastating and fatal multiorgan thrombosis. The patient, her mother, and her brother were found to have resistance to activated protein C (APC), and the congenital thrombophilia in this family was ver...

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Veröffentlicht in:American journal of hematology 1995-12, Vol.50 (4), p.292-295
Hauptverfasser: Gardyn, J., Sorkin, P., Kluger, Y., Kabili, S., Klausner, J. M., Zivelin, A., Eldor, A.
Format: Artikel
Sprache:eng
Schlagworte:
activated protein C resistance
Adult
Base Sequence
Biological and medical sciences
Colectomy
DNA - chemistry
Drug Resistance
Drug toxicity and drugs side effects treatment
Factor V - genetics
Fatal Outcome
Female
Heparin - adverse effects
heparin‐induced thrombocytopenia
Humans
Ileostomy
Medical sciences
Mesenteric Arteries
Molecular Sequence Data
Mutation
Pharmacology. Drug treatments
Protein C - pharmacology
Thrombocytopenia - chemically induced
thrombosis
Thrombosis - etiology
Thrombosis - surgery
Toxicity: blood
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Zusammenfassung:We report a 20‐year‐old woman who developed heparin‐induced thrombocytopenia (HIT) associated with devastating and fatal multiorgan thrombosis. The patient, her mother, and her brother were found to have resistance to activated protein C (APC), and the congenital thrombophilia in this family was verified by the finding of the Arg506 Gln mutation in factor V. This is the first case of HIT and APC resistance. The consequences of this association are discussed.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.2830500412