Cyclosporine for the treatment of granulocytopenia in Felty's syndrome

A patient with Felty's syndrome was treated with cyclosporine, initially 10 mg/kg/day and then 4 mg/kg/day. The neutrophil count increased by 6 weeks and was normal at 3 months. Over the subsequent 27 months the neutrophil count was closely related to the cyclosporine dosage and there was no ev...

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Veröffentlicht in:	American journal of hematology 1991-03, Vol.36 (3), p.219-220
Hauptverfasser:	Canvin, Janice M. G., Dalal, Bakul I., Baragar, Fletcher, Johnston, James B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agranulocytosis - drug therapy Agranulocytosis - etiology Biological and medical sciences Cell Count - drug effects Cyclosporins - therapeutic use Cyclosporins - toxicity Dose-Response Relationship, Drug Felty Syndrome - complications Felty Syndrome - drug therapy Humans Immunomodulators Male Medical sciences Middle Aged neutropenia neutrophil Neutrophils - drug effects Pharmacology. Drug treatments rheumatoid arthritis splenomegaly
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Zusammenfassung:	A patient with Felty's syndrome was treated with cyclosporine, initially 10 mg/kg/day and then 4 mg/kg/day. The neutrophil count increased by 6 weeks and was normal at 3 months. Over the subsequent 27 months the neutrophil count was closely related to the cyclosporine dosage and there was no evidence of cyclosporine toxicity. This case indicates that cyclosporine may have a role in the treatment of Felty's syndrome.
ISSN:	0361-8609 1096-8652
DOI:	10.1002/ajh.2830360315