Anterior uveitis as a complication of treatment with high dose cytosine‐arabinoside

We present a case of a 21‐year‐old woman suffering from diffuse large B‐cell lymphoma who developed acute anterior uveitis shortly after completing chemotherapeutic course with HYPER‐CVAD protocol (cyclophosphamide, doxorubicin, vincristine, and dexamethasone) alternating with methotrexate and high‐dose cytosine‐arabinoside (HIDAC), with poor adherence to recommended prophylactic treatment with saline eye drops. Complete resolution of her symptoms was achieved within a few days of treatment with topical steroids. To our knowledge this is the first report of acute anterior uveitis secondary to treatment with HIDAC. Differential diagnosis and a suggested mechanism are discussed. Am. J. Hematol. 76:304–306, 2004. © 2004 Wiley‐Liss, Inc.