DBSA‐Catalyzed Regioselective Dehydrative Friedel‐Crafts Arylation of CF 3 ‐Containing 3‐Indolyl(2‐thiophenyl)methanols with 2‐Substituted Indoles in Water
A green and efficient regioselective dehydrative Friedel‐Crafts arylation of trifluorinated 3‐indolyl(2‐thiophenyl) methanols with 2‐substituted indoles, catalyzed by DBSA (dodecylbenzenesulfonic acid) in water is described. This simple and atom‐economical protocol features a unique regioselective 1...
Gespeichert in:
| Veröffentlicht in: | Advanced synthesis & catalysis 2020-04, Vol.362 (7), p.1514-1524 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Zusammenfassung: | A green and efficient regioselective dehydrative Friedel‐Crafts arylation of trifluorinated 3‐indolyl(2‐thiophenyl) methanols with 2‐substituted indoles, catalyzed by DBSA (dodecylbenzenesulfonic acid) in water is described. This simple and atom‐economical protocol features a unique regioselective 1,8‐addition, operational simplicity, mild conditions, excellent functional group compatibility, and environmental benignity.
magnified image |
|---|---|
| ISSN: | 1615-4150 1615-4169 |
| DOI: | 10.1002/adsc.202000020 |