Copper‐Catalyzed CNH 2 Arylation of 2‐Aminobenzimidazoles and Related C‐Amino‐NH‐azoles
A copper(II)‐catalyzed selective CNH 2 arylation of 2‐aminobenzimidazoles and related C‐amino‐NH‐azoles was achieved in presence of 2,2′‐bipyridine and cesium carbonate at 60 °C under open air conditions and this is first method for the copper‐catalyzed selective CNH 2 arylation in the presence of...
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Veröffentlicht in: | Advanced synthesis & catalysis 2016-06, Vol.358 (13), p.2126-2133 |
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Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | A copper(II)‐catalyzed selective CNH
2
arylation of 2‐aminobenzimidazoles and related C‐amino‐NH‐azoles was achieved in presence of 2,2′‐bipyridine and cesium carbonate at 60 °C under open air conditions and this is first method for the copper‐catalyzed selective CNH
2
arylation in the presence of other reactive nucleophilic sites. Previously unexplored heteroaromatics possessing multiple nucleophilic sites that are selectively arylated at the CNH
2
position are obtained, providing an exceptional tool for rapid delivery of a diverse array of medicinally important CNH(aryl) derivatives of aminoazoles without any protection/deprotection of ring NH bonds. It is first example for the selective CNH
2
arylation of 5‐aminoindazole, 4‐aminopyrazole, 5‐aminopyrazole, 9
H
‐purine‐6‐amine, and 1
H
‐pyrazolo[3,4‐
d
]pyrimidin‐4‐amine derivatives.
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ISSN: | 1615-4150 1615-4169 |
DOI: | 10.1002/adsc.201600035 |