Quest for Efficient Catalysts based on Zinc tert ‐Butyl Peroxides for Asymmetric Epoxidation of Enones: C 2 ‐ vs C 1 ‐Symmetric Auxiliaries
Zinc tert ‐butyl peroxide‐based catalysts for the asymmetric epoxidation of enones using tert ‐butyl hydroperoxide as an oxidant have been developed. A comparative study of chiral monoanioninc N , N′ ‐bidentate ligands, C 2 ‐symmetric bisoxazolinates and C 1 ‐symmetric enaminooxazolinates, revealed...
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| Veröffentlicht in: | Advanced synthesis & catalysis 2016-03, Vol.358 (6), p.864-868 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Zinc
tert
‐butyl peroxide‐based catalysts for the asymmetric epoxidation of enones using
tert
‐butyl hydroperoxide as an oxidant have been developed. A comparative study of chiral monoanioninc
N
,
N′
‐bidentate ligands,
C
2
‐symmetric bisoxazolinates and
C
1
‐symmetric enaminooxazolinates, revealed excellent performance of
C
1
‐symmetric auxiliary ligands on catalytic asymmetric epoxidation of enones (up to 96% yield, 91%
ee
).
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| ISSN: | 1615-4150 1615-4169 |
| DOI: | 10.1002/adsc.201500764 |