SIAPhos: Phosphorylated Sulfonimidamides and their Use in Iridium-Catalyzed Asymmetric Hydrogenations of Sterically Hindered Cyclic Enamides

Phosphorylated sulfonimidamides (SIAPhos) undergo ion exchange reactions with cationic complexes, [Rh(cod)2BF4] and [Ir(cod)2BarF], or neutral complexes [Rh(cod)Cl]2 and [Ir(cod)Cl]2, leading to unprecedented neutral complexes with P‐N‐S‐N chelates. Use of the resulting neutral iridium complexes in...

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Veröffentlicht in:	Advanced synthesis & catalysis 2012-01, Vol.354 (1), p.59-64
Hauptverfasser:	Patureau, Frederic W., Worch, Christin, Siegler, Maxime A., Spek, Anthony L., Bolm, Carsten, Reek, Joost N. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	asymmetric hydrogenation Catalysis Catalysts: preparations and properties Chemistry Exact sciences and technology General and physical chemistry iridium Kinetics and mechanisms Organic chemistry phosphorylated sulfonimidamides (SIAPhos) Reactivity and mechanisms SIAPhos (phosphorylated sulfonimidamides) sulfonimidamides sulfur chirality Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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Beschreibung
Zusammenfassung:	Phosphorylated sulfonimidamides (SIAPhos) undergo ion exchange reactions with cationic complexes, [Rh(cod)2BF4] and [Ir(cod)2BarF], or neutral complexes [Rh(cod)Cl]2 and [Ir(cod)Cl]2, leading to unprecedented neutral complexes with P‐N‐S‐N chelates. Use of the resulting neutral iridium complexes in asymmetric hydrogenation reactions of tri‐ and tetrasubstituted enamides leads to products with high enantioselectivities (up to 92% ee).
ISSN:	1615-4150 1615-4169
DOI:	10.1002/adsc.201100692