Diastereoselective and Highly Enantioselective Henry Reactions using C 1 ‐Symmetrical Copper(II) Complexes

Diastereoselective and Highly Enantioselective Henry Reactions using C 1 ‐Symmetrical Copper(II) Complexes

Catalytic Henry reactions of aliphatic aldehydes and prochiral nitro compounds were investigated using copper(II) complexes of 14 C 1 ‐symmetrical ligands derived from (1 R ,2 R )(−)‐diaminocyclohexane. β‐Nitro alcohols with syn : anti ratios of up to 5.7 and excellent ee values for both diastereosi...

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Veröffentlicht in:Advanced synthesis & catalysis 2011-07, Vol.353 (10), p.1797-1806
Hauptverfasser: Chougnet, Antoinette, Zhang, Guoqi, Liu, Kegang, Häussinger, Daniel, Kägi, Andreas, Allmendinger, Thomas, Woggon, Wolf‐D.
Format: Artikel
Sprache:eng
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Zusammenfassung:Catalytic Henry reactions of aliphatic aldehydes and prochiral nitro compounds were investigated using copper(II) complexes of 14 C 1 ‐symmetrical ligands derived from (1 R ,2 R )(−)‐diaminocyclohexane. β‐Nitro alcohols with syn : anti ratios of up to 5.7 and excellent ee values for both diastereosimers were obtained.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201100157