Synthesis of Azomethines from α-Oxocarboxylates, Amines and Aryl Bromides via One-Pot Three-Component Decarboxylative Coupling

A bimetallic palladium/copper catalyst system allows the highly modular synthesis of azomethines via the decarboxylative coupling of aryl halides and α‐iminocarboxylates, generated in situ from potassium α‐oxocarboxylates and primary amines. The reaction proceeds already at 100 °C, a new record for...

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Veröffentlicht in:	Advanced synthesis & catalysis 2011-02, Vol.353 (2-3), p.337-342
Hauptverfasser:	Rudolphi, Felix, Song, Bingrui, Gooßen, Lukas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Catalysts: preparations and properties Chemistry copper cross-coupling decarboxylation Exact sciences and technology General and physical chemistry Kinetics and mechanisms multicomponent reactions Organic chemistry palladium Reactivity and mechanisms Schiff bases Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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Beschreibung
Zusammenfassung:	A bimetallic palladium/copper catalyst system allows the highly modular synthesis of azomethines via the decarboxylative coupling of aryl halides and α‐iminocarboxylates, generated in situ from potassium α‐oxocarboxylates and primary amines. The reaction proceeds already at 100 °C, a new record for redox‐neutral decarboxylative cross‐coupling reactions.
ISSN:	1615-4150 1615-4169
DOI:	10.1002/adsc.201000798