A Direct Synthesis of Symmetrical (E,E)-1,4-Diaryl-1,3-butadienes by Wenkert Arylation of Thiophene

A Direct Synthesis of Symmetrical (E,E)-1,4-Diaryl-1,3-butadienes by Wenkert Arylation of Thiophene

The nickel‐catalyzed coupling of thiophene with aryl Grignard reagents (Wenkert reaction) is accelerated by N‐heterocyclic carbene or trialkylphosphane ligands, providing a general, scalable direct synthesis of symmetrical 1,4‐diarylbutadienes.

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Veröffentlicht in:Advanced synthesis & catalysis 2010-10, Vol.352 (14-15), p.2411-2415
Hauptverfasser: Hintermann, Lukas, Schmitz, Marco, Chen, Yun
Format: Artikel
Sprache:eng
Schlagworte:
alkenes
cross-coupling
homogeneous catalysis
nickel
sulfur heterocycles
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Beschreibung
Zusammenfassung:The nickel‐catalyzed coupling of thiophene with aryl Grignard reagents (Wenkert reaction) is accelerated by N‐heterocyclic carbene or trialkylphosphane ligands, providing a general, scalable direct synthesis of symmetrical 1,4‐diarylbutadienes.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201000350