A Combinatorial Approach to Heterogeneous Asymmetric Aquacatalysis with Amphiphilic Polymer-Supported Chiral Phosphine-Palladium Complexes

A Combinatorial Approach to Heterogeneous Asymmetric Aquacatalysis with Amphiphilic Polymer-Supported Chiral Phosphine-Palladium Complexes

A library of amphiphlic polystyrene‐poly(ethylene glycol) (PS‐PEG) resin‐supported chiral phosphine ligands was prepared by the split method using porous miniature reactors. A polymeric (R)‐2‐(diphenylphosphino)binaphthyl (MOP) ligand anchored onto the PS‐PEG resin by an (S)‐alanine tether unit was...

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Veröffentlicht in:Advanced synthesis & catalysis 2006-08, Vol.348 (12-13), p.1561-1566
Hauptverfasser: Kobayashi, Yukinari, Tanaka, Daiki, Danjo, Hiroshi, Uozumi, Yasuhiro
Format: Artikel
Sprache:eng
Schlagworte:
allylic substitution
aqueous media
asymmetric catalysis
combinatorial chemistry
palladium
polymer-supported catalyst
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Zusammenfassung:A library of amphiphlic polystyrene‐poly(ethylene glycol) (PS‐PEG) resin‐supported chiral phosphine ligands was prepared by the split method using porous miniature reactors. A polymeric (R)‐2‐(diphenylphosphino)binaphthyl (MOP) ligand anchored onto the PS‐PEG resin by an (S)‐alanine tether unit was identified through the library‐based screening to be an effective chiral ligand for the asymmetric palladium‐catalyzed π‐allylic substitution under heterogeneous aqueous conditions.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200606146