Iridium-Catalyzed Enantioselective [2+2+2] Cycloaddition of Diynes and Monoalkynes for the Generation of Axial Chiralities

Iridium-Catalyzed Enantioselective [2+2+2] Cycloaddition of Diynes and Monoalkynes for the Generation of Axial Chiralities

A highly enantioselective intermolecular [2+2+2] cycloaddition of alkynes was catalyzed by a chiral iridium complex. Symmetrical and unsymmetrical diynes, and monoalkynes possessing functional group(s) were subjected to the reaction and various types of axially chiral compounds possessing biaryl ske...

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Veröffentlicht in:Advanced synthesis & catalysis 2006-11, Vol.348 (16-17), p.2475-2483
Hauptverfasser: Shibata, Takanori, Arai, Yoshikazu, Takami, Kyoko, Tsuchikama, Kyoji, Fujimoto, Takayoshi, Takebayashi, Satoshi, Takagi, Kentaro
Format: Artikel
Sprache:eng
Schlagworte:
asymmetric catalysis
chirality
cycloaddition
enantioselectivity
iridium
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Zusammenfassung:A highly enantioselective intermolecular [2+2+2] cycloaddition of alkynes was catalyzed by a chiral iridium complex. Symmetrical and unsymmetrical diynes, and monoalkynes possessing functional group(s) were subjected to the reaction and various types of axially chiral compounds possessing biaryl skeletons were obtained in good to excellent enantiomeric excesses.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200600317