Highly Enantioselective Iridium-Catalyzed Hydrogenation of Quinoline Derivatives Using Chiral Phosphinite H8-BINAPO

Highly Enantioselective Iridium-Catalyzed Hydrogenation of Quinoline Derivatives Using Chiral Phosphinite H8-BINAPO

The chiral diphosphinite H8‐BINAPO derived from H8‐BINOL has been used in the Ir‐catalyzed asymmetric hydrogenation of quinolines, and high enantioselectivity (up to 97% ee) was obtained. Immobilization of the iridium catalyst in poly(ethylene glycol) dimethyl ether (DMPEG) is also discussed. With D...

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Veröffentlicht in:Advanced synthesis & catalysis 2005-11, Vol.347 (14), p.1755-1758
Hauptverfasser: Lam, Kim Hung, Xu, Lijin, Feng, Lichun, Fan, Qing-Hua, Lam, Fuk Loi, Lo, Wai-hung, Chan, Albert S. C.
Format: Artikel
Sprache:eng
Schlagworte:
asymmetric hydrogenation
immobilization
iridium
phosphinite ligands
poly(ethylene glycol) dimethyl ether
quinoline
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Zusammenfassung:The chiral diphosphinite H8‐BINAPO derived from H8‐BINOL has been used in the Ir‐catalyzed asymmetric hydrogenation of quinolines, and high enantioselectivity (up to 97% ee) was obtained. Immobilization of the iridium catalyst in poly(ethylene glycol) dimethyl ether (DMPEG) is also discussed. With DMPEG/hexane biphasic system, better enantioselectivities were obtained as compared to those observed in aprotic organic solvents.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200505130