Ultrasensitive Detection and Cellular Photothermal Therapy via a Self‐Photothermal Modulation Biosensor (Advanced Optical Materials 8/2023)

An optical microfiber sensor with well‐distributed plasmonic hotspot enhancement was used by Yunyun Huang, Bai‐Ou Guan, and co‐workers (article number 2202711) to detect alpha‐fetoprotein with a temperature‐tunable sensitivity, and to differentiate hepatoma carcinoma cells from normal cells and provide photothermal therapy aimed at the former. This work provides a new opportunity for selective evanescent field modulation for evanescent biosensors as well as a potential approach to the integration of cellular diagnosis and therapy.