A Pathomimetic Colorectal Tumor‐on‐a‐Chip for In Vitro Reconstitution of the Primary Colorectal Cancer (Adv. Mater. Technol. 13/2023)

Tumor on a Chip In article number 2200758, Lu Huang and co‐workers propose a pathomimetic colorectal tumor‐on‐a‐chip (CRT‐chip) that can effectively recapitulate the in vivo dynamic physiology and pathology of primary colorectal cancer (CRC). The cover figure demonstrates the analogy between the CRT‐chips and the in vivo primary CRC. The central channel seeded with epithelial cells mimics the epithelium layer of colorectum. The tumor cells loaded in the microchamber emulate the site‐specific primary CRC. The bottom channel underneath the microchamber recapitulates the in vivo tumor vessels.