Enhanced Competition at the Nano–Bio Interface Enables Comprehensive Characterization of Protein Corona Dynamics and Deep Coverage of Proteomes (Adv. Mater. 44/2022)

Proteomics In article number 2206008, Omid C. Farokhzad, Daniel Hornburg, and co‐workers show how the Vroman effect can be leveraged to capture the complexity of human proteomes using engineered nanoparticles. Protein corona formation dynamics demonstrate how nanoparticle functionalization and nano–bio binding competition enable deep and quantitative interrogation of biosamples. This facilitates increased capture of low‐abundance proteins, including cytokines and chemokines, enabling new strategies for biomarker discovery and personalized nanomedicine.