Cell-Responsive Synthetic Hydrogels

Cell-Responsive Synthetic Hydrogels

Synthetic biomaterial matrices have been formed in the presence of cells by a Michael‐type addition reaction between a difunctional protease substrate peptide, a monofunctional cell adhesion peptide, and a tetrafunctional poly(ethylene glycol). These materials locally degrade in response to cell‐sur...

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Veröffentlicht in:Advanced materials (Weinheim) 2003-06, Vol.15 (11), p.888-892
Hauptverfasser: Lutolf, M.P., Raeber, G.P., Zisch, A.H., Tirelli, N., Hubbell, J.A.
Format: Artikel
Sprache:eng
Schlagworte:
Biomaterials
Cells
Hydrogels
Peptides
Tissue engineering
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Beschreibung
Zusammenfassung:Synthetic biomaterial matrices have been formed in the presence of cells by a Michael‐type addition reaction between a difunctional protease substrate peptide, a monofunctional cell adhesion peptide, and a tetrafunctional poly(ethylene glycol). These materials locally degrade in response to cell‐surface proteases, allowing cells to create paths for 3D cell migration (see Figure).
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200304621