Hypoxia: Evaluating CAR‐T Cell Therapy in a Hypoxic 3D Tumor Model (Adv. Healthcare Mater. 5/2019)

Hypoxia: Evaluating CAR‐T Cell Therapy in a Hypoxic 3D Tumor Model (Adv. Healthcare Mater. 5/2019)

Hypoxia is a feature of most solid tumor microenvironments. Chimeric antigen receptor T (CAR‐T) cell therapy has not been successful in solid tumors, partially due to the tumor microenvironment. In article number 1900001 by Keyue Shen and co‐workers, an in vitro hypoxic tumor model with an oxygen gr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Advanced healthcare materials 2019-03, Vol.8 (5), p.n/a
Hauptverfasser: Ando, Yuta, Siegler, Elizabeth L., Ta, Hoang P., Cinay, Gunce E., Zhou, Hao, Gorrell, Kimberly A., Au, Hannah, Jarvis, Bethany M., Wang, Pin, Shen, Keyue
Format: Artikel
Sprache:eng
Schlagworte:
chimeric antigen receptors
hypoxia
immune checkpoints
immunotherapy
ovarian cancer
solid tumors
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Hypoxia is a feature of most solid tumor microenvironments. Chimeric antigen receptor T (CAR‐T) cell therapy has not been successful in solid tumors, partially due to the tumor microenvironment. In article number 1900001 by Keyue Shen and co‐workers, an in vitro hypoxic tumor model with an oxygen gradient is engineered, which allows for quantitative assessment of CAR‐T cell cytotoxicity and infiltration under the heterogeneous oxygen landscape in solid tumors.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201970015