Boosting Antitumor Immunity via a Tumor Microenvironment‐Responsive Transformable Trifecta Nanovaccine (Adv. Funct. Mater. 26/2024)

Boosting Antitumor Immunity via a Tumor Microenvironment‐Responsive Transformable Trifecta Nanovaccine (Adv. Funct. Mater. 26/2024)

Nanovaccines In article number 2311480, Yongbin Mou, Zhaogang Teng, Heng Dong, and co‐workers present a tumor microenvironment‐responsive and soft‐transformable nanovaccine that comprehensively addresses the major obstacles faced by in situ tumor vaccines. It includes promoting immunogenic cell deat...

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Veröffentlicht in:Advanced functional materials 2024-06, Vol.34 (26), p.n/a
Hauptverfasser: Li, Qiang, Dang, Meng, Tao, Jun, Li, Xiaoye, Xiu, Weijun, Dai, Zhuo, He, Ao, Ding, Meng, Zhang, Yu, Wen, Zhi‐fa, Su, Xiaodan, Elbourne, Aaron James, Bao, Lei, Chen, Lin, Mou, Yongbin, Teng, Zhaogang, Dong, Heng
Format: Artikel
Sprache:eng
Schlagworte:
cGAS‐stimulator of interferon genes signaling pathway
in situ nanovaccines, metal oxide hybrid mesoporous organosilica nanoparticles, tumor immunotherapy, tumor microenvironment‐responsive nanoparticles
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Zusammenfassung:Nanovaccines In article number 2311480, Yongbin Mou, Zhaogang Teng, Heng Dong, and co‐workers present a tumor microenvironment‐responsive and soft‐transformable nanovaccine that comprehensively addresses the major obstacles faced by in situ tumor vaccines. It includes promoting immunogenic cell death in tumor cells, fostering dendritic cell maturation, and encouraging macrophage M1 polarization, all while reprogramming the immunosuppressive tumor microenvironment.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202470141