Extracellular Matrix Remodelling: Obesity‐Associated Adipose Stromal Cells Promote Breast Cancer Invasion through Direct Cell Contact and ECM Remodeling (Adv. Funct. Mater. 48/2020)

Extracellular Matrix Remodelling: Obesity‐Associated Adipose Stromal Cells Promote Breast Cancer Invasion through Direct Cell Contact and ECM Remodeling (Adv. Funct. Mater. 48/2020)

In article number 1910650, Claudia Fischbach and co‐workers combine collagen‐embedded multicellular spheroids and advanced imaging to investigate the effect of adipose stromal cells (ASCs) on tumor cell invasion as a function of obesity. Obese ASCs increase collective tumor cell migration relative t...

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Veröffentlicht in:Advanced functional materials 2020-11, Vol.30 (48), p.n/a
Hauptverfasser: Ling, Lu, Mulligan, Jeffrey A., Ouyang, Yunxin, Shimpi, Adrian A., Williams, Rebecca M., Beeghly, Garrett F., Hopkins, Benjamin D., Spector, Jason A., Adie, Steven G., Fischbach, Claudia
Format: Artikel
Sprache:eng
Schlagworte:
collagen
extracellular matrix remodeling
obesity
optical coherence tomography
tumor invasion
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Zusammenfassung:In article number 1910650, Claudia Fischbach and co‐workers combine collagen‐embedded multicellular spheroids and advanced imaging to investigate the effect of adipose stromal cells (ASCs) on tumor cell invasion as a function of obesity. Obese ASCs increase collective tumor cell migration relative to lean ASCs by stimulating proteolytic and contractility‐dependent collagen remode ling, providing insights into how obesity promotes breast cancer malignancy.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202070320