Extracellular Delivery: Tumor Microenvironment‐Tailored Weakly Cell‐Interacted Extracellular Delivery Platform Enables Precise Antibody Release and Function (Adv. Funct. Mater. 43/2019)

Extracellular Delivery: Tumor Microenvironment‐Tailored Weakly Cell‐Interacted Extracellular Delivery Platform Enables Precise Antibody Release and Function (Adv. Funct. Mater. 43/2019)

In article number 1903296, Jin Zhao, Xubo Yuan, Chunsheng Kang, and co‐workers report a weakly cell‐interacted, nanosized, environment‐responsive delivery platform (WINNER) for precise extracellular release of extracellularly functional protein drugs. The WINNER can protect the inner drugs from cell...

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Veröffentlicht in:Advanced functional materials 2019-10, Vol.29 (43), p.n/a
Hauptverfasser: Li, Sidi, Chen, Luyang, Huang, Kai, Chen, Ning, Zhan, Qi, Yi, Kaikai, Qi, Hongzhao, Liu, Chaoyong, Tan, Yanli, Hou, Xin, Lu, Yunfeng, Zhao, Jin, Yuan, Xubo, Kang, Chunsheng
Format: Artikel
Sprache:eng
Schlagworte:
cellular uptake
enzymatic degradation
extracellular release
phosphorylcholine
weak interaction
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Zusammenfassung:In article number 1903296, Jin Zhao, Xubo Yuan, Chunsheng Kang, and co‐workers report a weakly cell‐interacted, nanosized, environment‐responsive delivery platform (WINNER) for precise extracellular release of extracellularly functional protein drugs. The WINNER can protect the inner drugs from cellular uptake and undergo enzymatic degradation in the tumor microenvironment to uncage the therapeutic power of the therapeutic agents.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.201970301