Hyperammonemia: Liposome-Supported Peritoneal Dialysis for the Treatment of Hyperammonemia-Associated Encephalopathy (Adv. Funct. Mater. 46/2016)

Hyperammonemia: Liposome-Supported Peritoneal Dialysis for the Treatment of Hyperammonemia-Associated Encephalopathy (Adv. Funct. Mater. 46/2016)

On page 8382, J.‐C. Leroux and co‐workers describe a novel approach for treating hyperammonemia induced encephalopathy, based on the peritoneal infusion of giant transmembrane pH‐gradient liposomes bearing an acidic core. These scavenging vesicles allow a safe and effective removal of excess ammonia...

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Veröffentlicht in:Advanced functional materials 2016-12, Vol.26 (46), p.8357-8357
Hauptverfasser: Agostoni, Valentina, Lee, Soo Hyeon, Forster, Vincent, Kabbaj, Meriam, Bosoi, Cristina R., Tremblay, Mélanie, Zadory, Matthias, Rose, Christopher F., Leroux, Jean-Christophe
Format: Artikel
Sprache:eng
Schlagworte:
detoxification
hepatic encephalopathy
hyperammonemia
liposomes
peritoneal dialysis
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Zusammenfassung:On page 8382, J.‐C. Leroux and co‐workers describe a novel approach for treating hyperammonemia induced encephalopathy, based on the peritoneal infusion of giant transmembrane pH‐gradient liposomes bearing an acidic core. These scavenging vesicles allow a safe and effective removal of excess ammonia, outperforming conventional peritoneal dialysis fluids and significantly attenuating brain edema in a rodent model of liver disease.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.201670300