Retargeting adenoviruses for therapeutic applications and vaccines

Adenoviruses (Ads) are robust vectors for therapeutic applications and vaccines, but their use can be limited by differences in their in vitro and in vivo pharmacologies. This review emphasizes that there is not just one Ad, but a whole virome of diverse viruses that can be used as therapeutics. It...

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Veröffentlicht in:	FEBS letters 2020-06, Vol.594 (12), p.1918-1946
Hauptverfasser:	Barry, Michael A., Rubin, Jeffrey D., Lu, Shao‐Chia
Format:	Artikel
Sprache:	eng
Schlagworte:	Ad serotypes Adenoviridae - classification Adenoviridae - genetics Animals Biotinylation Capsid Proteins - genetics detargeting gain of function Genetic Vectors - administration & dosage Genetic Vectors - genetics Genetic Vectors - pharmacokinetics Humans Injections, Intravenous Ligands liver Liver - drug effects Microorganisms, Genetically-Modified Oncolytic Viruses - genetics Peptide Library retargeting sequestration serotypes Tissue Distribution Vaccines - administration & dosage Vaccines - genetics
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Beschreibung
Zusammenfassung:	Adenoviruses (Ads) are robust vectors for therapeutic applications and vaccines, but their use can be limited by differences in their in vitro and in vivo pharmacologies. This review emphasizes that there is not just one Ad, but a whole virome of diverse viruses that can be used as therapeutics. It discusses that true vector targeting involves not only retargeting viruses, but importantly also detargeting the viruses from off‐target cells.
ISSN:	0014-5793 1873-3468
DOI:	10.1002/1873-3468.13731