Olefin Cross‐Metathesis for the Synthesis of Alkenyl Acyclonucleoside Phosphonates

Olefin Cross‐Metathesis for the Synthesis of Alkenyl Acyclonucleoside Phosphonates

The detailed synthetic protocol for the straightforward, efficient synthesis of various alkenyl acyclonucleosides, including challenging trisubstituted alkenyl acyclonucleoside phosphonates, is described. The key step of those syntheses is an olefin cross‐metathesis reaction between two olefins sele...

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Veröffentlicht in:Current Protocols in Nucleic Acid Chemistry 2014-12, Vol.59 (1), p.14.11.1-14.11.17
Hauptverfasser: Bessières, Maxime, De Schutter, Coralie, Roy, Vincent, Agofoglio, Luigi A.
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
chemical
nucleosides
Nucleosides - chemical synthesis
Nucleosides - chemistry
olefin cross‐metathesis
prodrug
Ruthenium - chemistry
ruthenium catalyst
synthesis
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Zusammenfassung:The detailed synthetic protocol for the straightforward, efficient synthesis of various alkenyl acyclonucleosides, including challenging trisubstituted alkenyl acyclonucleoside phosphonates, is described. The key step of those syntheses is an olefin cross‐metathesis reaction between two olefins selected based on their reactivity using well‐defined ruthenium alkylidene catalysts. © 2014 by John Wiley & Sons, Inc.
ISSN:1934-9270
1934-9289
DOI:10.1002/0471142700.nc1411s59