Enzymatic Synthesis of M 1 G‐Deoxyribose
Adducts formed between electrophiles and nucleic acid bases are believed to play a key role in chemically induced mutations and cancer. M 1 G‐dR is an endogenous exocyclic DNA adduct formed by the reaction of the dicarbonyl compound malondialdehyde with a dG residue in DNA. It is an intermediate in...
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Veröffentlicht in: | Current Protocols in Nucleic Acid Chemistry 2000-02 (1) |
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creator | Schnetz‐Boutaud, Nathalie C. Chapeau, Marie‐Christine Marnett, Lawrence J. |
description | Adducts formed between electrophiles and nucleic acid bases are believed to play a key role in chemically induced mutations and cancer. M
1
G‐dR is an endogenous exocyclic DNA adduct formed by the reaction of the dicarbonyl compound malondialdehyde with a dG residue in DNA. It is an intermediate in the synthesis of a class of modified oligodeoxyribonucleotides that are used to study the mutagenicity and repair of M
1
G. This unit presents methods for synthesizing M
1
G‐dR by enzymatic coupling. |
doi_str_mv | 10.1002/0471142700.nc0102s00 |
format | Article |
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1
G‐dR is an endogenous exocyclic DNA adduct formed by the reaction of the dicarbonyl compound malondialdehyde with a dG residue in DNA. It is an intermediate in the synthesis of a class of modified oligodeoxyribonucleotides that are used to study the mutagenicity and repair of M
1
G. This unit presents methods for synthesizing M
1
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1
G‐dR is an endogenous exocyclic DNA adduct formed by the reaction of the dicarbonyl compound malondialdehyde with a dG residue in DNA. It is an intermediate in the synthesis of a class of modified oligodeoxyribonucleotides that are used to study the mutagenicity and repair of M
1
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1
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1
G‐dR is an endogenous exocyclic DNA adduct formed by the reaction of the dicarbonyl compound malondialdehyde with a dG residue in DNA. It is an intermediate in the synthesis of a class of modified oligodeoxyribonucleotides that are used to study the mutagenicity and repair of M
1
G. This unit presents methods for synthesizing M
1
G‐dR by enzymatic coupling.</abstract><doi>10.1002/0471142700.nc0102s00</doi></addata></record> |
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title | Enzymatic Synthesis of M 1 G‐Deoxyribose |
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