Zebrafish: An Animal Model for Toxicological Studies

Zebrafish (Danio rerio) has been extensively studied and well described for environmental toxicity studies. Molecular biology and genetics have recently been used to elucidate the underlying mechanisms of toxicity in zebrafish and to predict effects in mammals. The versatile zebrafish is now incorpo...

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Veröffentlicht in:	Current Protocols in Toxicology 2003-08, Vol.17 (1), p.1.7.1-1.7.18
Hauptverfasser:	Zhang, Chaojie, Willett, Catherine, Fremgen, Trisha
Format:	Artikel
Sprache:	eng
Schlagworte:	animal model Animal Use Alternatives - methods Animals developmental toxicity drug testing Drug-Related Side Effects and Adverse Reactions Ecotoxicology - methods Embryo, Nonmammalian - drug effects Embryonic Development - drug effects Endocrine Disruptors - toxicity Mutagens - toxicity Organ Specificity Teratogens - toxicity toxicity Toxicology - methods zebrafish Zebrafish - embryology Zebrafish - genetics
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Beschreibung
Zusammenfassung:	Zebrafish (Danio rerio) has been extensively studied and well described for environmental toxicity studies. Molecular biology and genetics have recently been used to elucidate the underlying mechanisms of toxicity in zebrafish and to predict effects in mammals. The versatile zebrafish is now incorporated in many areas of toxicological programs for assessing human risk and for preclinical drug discovery and screening.
ISSN:	1934-9254 1934-9262
DOI:	10.1002/0471140856.tx0107s17