Association of GSK3β Polymorphisms With Brain Structural Changes in Major Depressive Disorder
CONTEXT Indirect evidence suggests that the glycogen synthase kinase-3β (GSK3β) gene might be implicated in major depressive disorder (MDD). BACKGROUND We evaluated 15 GSK3β single-nucleotide polymorphisms (SNPs) to test for associations with regional gray matter (GM) volume differences in patients...
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Veröffentlicht in: | Archives of general psychiatry 2009-07, Vol.66 (7), p.721-728 |
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Sprache: | eng |
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Zusammenfassung: | CONTEXT Indirect evidence suggests that the glycogen synthase kinase-3β (GSK3β) gene might be implicated in major depressive disorder (MDD). BACKGROUND We evaluated 15 GSK3β single-nucleotide polymorphisms (SNPs) to test for associations with regional gray matter (GM) volume differences in patients with recurrent MDD. We then used the defined regions of interest based on significant associations to test for MDD × genotype interactions by including a matched control group without any psychiatric disorder, including MDD. DESIGN General linear model with nonstationary cluster-based inference. SETTING Munich, Germany. PARTICIPANTS Patients with recurrent MDD (n = 134) and age-, sex-, and ethnicity-matched healthy controls (n = 143). MAIN OUTCOME MEASURES Associations between GSK3β polymorphisms and regional GM volume differences. RESULTS Variation in GM volume was associated with GSK3β polymorphisms; the most significant associations were found for rs6438552, a putative functional intronic SNP that showed 3 significant GM clusters in the right and left superior temporal gyri and the right hippocampus (P |
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ISSN: | 0003-990X 1538-3636 |
DOI: | 10.1001/archgenpsychiatry.2009.70 |