Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers

Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers

Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. To identify novel and pleotropic SqC...

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Hauptverfasser: Lesseur, Corina, Ferreiro-Iglesias, Aida, McKay, James D, Bossé, Yohan, Johansson, Mattias, Gaborieau, Valerie, Landi, Maria Teresa, Christiani, David C, Caporaso, Neil E, Bojesen, Stig E, Amos, Christopher I, Shete, Sanjay S, Liu, Geoffrey, Rennert, Gadi, Albanes, Demetrius, Aldrich, Melinda C, Tardon, Adonina, Chen, Chu, Triantafillos, Liloglou, Field, John K, Teare, Marion Dawn, Kiemeney, Lambertus A, Diergaarde, Brenda, Ferris, Robert L, Zienolddiny, Shanbeh, Lam, Stephen, Olshan, Andrew F, Weissler, Mark C, Lacko, Martin, Risch, Angela, Bickeböller, Heike, Ness, Andy R, Thomas, Steve, Le Marchand, Loïc, Schabath, Matthew B, Wunsch-Filho, Victor, Tajara, Eloiza H, Andrew, Angeline S, Clifford, Gary M, Lazarus, Philip, Grankvist, Kjell, Johansson, Mikael, Arnold, Susanne, Melander, Olle, Brunnström, Hans, Boccia, Stefania, Cadoni, Gabriella, Timens, Wim, Obeidat, Ma’en, Xiao, Xiangjun, Houlston, Richard S, Hung, Rayjean J, Brennan, Paul
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Sprache:eng
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Zusammenfassung:Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. To identify novel and pleotropic SqCC risk variants, we performed a meta-analysis of GWAS data on lung SqCC (LuSqCC), oro/pharyngeal SqCC (OSqCC), laryngeal SqCC (LaSqCC) and esophageal SqCC (ESqCC) cancers, totaling 13,887 cases and 61,961 controls of European ancestry. We identified one novel genome-wide significant (Pmeta