Pre-treatment levels of inflammatory markers and chemotherapy completion rates in patients with early-stage breast cancer

Pre-treatment levels of inflammatory markers and chemotherapy completion rates in patients with early-stage breast cancer

Background Chemotherapy efficacy is largely dependent on treatment adherence, defned by the relative dose intensity (RDI). Identifcation of new modifable risk factors associated with low RDI might improve chemotherapy delivery. Here, we evaluated the association between low RDI and pre-chemotherapy...

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Hauptverfasser: Schauer, Tim, Henriksson, Anna, Strandberg, Emelie, Lindman, Henrik, Berntsen, Sveinung, Demmelmaier, Ingrid, Raastad, Truls, Nordin, Karin, Christensen, Jesper F
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Sprache:eng
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Zusammenfassung:Background Chemotherapy efficacy is largely dependent on treatment adherence, defned by the relative dose intensity (RDI). Identifcation of new modifable risk factors associated with low RDI might improve chemotherapy delivery. Here, we evaluated the association between low RDI and pre-chemotherapy factors, including patient- and treatment-related characteristics and markers of infammation. Methods This exploratory analysis assessed data from 267 patients with early-stage breast cancer scheduled to undergo (neo-)adjuvant chemotherapy included in the Physical training and Cancer (Phys-Can) trial. The association between low RDI, defned as