Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity

Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity

Adiponectin/leptin ratio, triacylglycerols, and waist-to-hip ratio explained almost half of HOMA-IR variance in the context of obesity. This study provides evidence to support adipose tissue dysfunction as a central feature of the pathophysiology of obesity and insulin resistance. Early identificati...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Castela, Inês, Morais, Juliana, Barreiros-Mota, Inês, Silvestre, Marta P, Marques, Cláudia, Rodrigues, Catarina, Ismael, Shámila, Araújo, João R, Ângelo-Dias, Miguel, Martins, Catarina, Borrego, Luís Miguel, Monteiro, Rosário, dos Santos Ribeiro F. Coutinho, Silvia, Calhau, Conceição, Alho Letra Martins, Catia Patricia, Faria, Ana, Pestana, Diogo, Teixeira, Diana
Format: Artikel
Sprache:eng
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Adiponectin/leptin ratio, triacylglycerols, and waist-to-hip ratio explained almost half of HOMA-IR variance in the context of obesity. This study provides evidence to support adipose tissue dysfunction as a central feature of the pathophysiology of obesity and insulin resistance. Early identification of individuals at higher risk of developing metabolic complications through adipose tissue dysfunction assessment and the staging of obesity and its transient phenotypes can contribute to improve therapeutic decision-making.