The blood proteome of imminent lung cancer diagnosis

The blood proteome of imminent lung cancer diagnosis

Identification of risk biomarkers may enhance early detection of smoking-related lung cancer. We measured between 392 and 1,162 proteins in blood samples drawn at most three years before diagnosis in 731 smoking-matched case-control sets nested within six prospective cohorts from the US, Europe, Sin...

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Hauptverfasser: Albanes, Demetrius, Alcala, Karine, Alcala, Nicolas, Amos, Christopher I, Arslan, Alan A, Bassett, Julie K, Brennan, Paul, Cai, Qiuyin, Chen, Chu, Feng, Xiaoshuang, Freedman, Neal D, Guida, Florence, Hung, Rayjean J, Hveem, Kristian, Johansson, Mikael, Johansson, Mattias, Koh, Woon-Puay, Langhammer, Arnulf, Milne, Roger L, Muller, David, Onwuka, Justina, Sørgjerd, Elin Pettersen, Robbins, Hilary A, Sesso, Howard D, Severi, Gianluca, Shu, Xiao-Ou, Sieri, Sabina, Smith-Byrne, Karl, Stevens, Victoria, Tinker, Lesley, Tjønneland, Anne, Visvanathan, Kala, Wang, Ying, Wang, Renwei, Weinstein, Stephanie, Yuan, Jian-Min, Zahed, Hana, Zhang, Xuehong, Zheng, Wei
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Sprache:eng
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Zusammenfassung:Identification of risk biomarkers may enhance early detection of smoking-related lung cancer. We measured between 392 and 1,162 proteins in blood samples drawn at most three years before diagnosis in 731 smoking-matched case-control sets nested within six prospective cohorts from the US, Europe, Singapore, and Australia. We identify 36 proteins with independently reproducible associations with risk of imminent lung cancer diagnosis (all p