Pre-treatment levels of inflammatory markers and chemotherapy completion rates in patients with early-stage breast cancer

Pre-treatment levels of inflammatory markers and chemotherapy completion rates in patients with early-stage breast cancer

Background Chemotherapy efcacy is largely dependent on treatment adherence, defned by the relative dose intensity (RDI). Identifcation of new modifable risk factors associated with low RDI might improve chemotherapy delivery. Here, we evaluated the association between low RDI and pre-chemotherapy fa...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Schauer, Tim, Henriksson, Anna, Strandberg, Emelie, Lindman, Henrik, Berntsen, Sveinung, Demmelmaier, Ingrid, Raastad, Truls, Nordin, Karin, Christensen, Jesper F
Format: Artikel
Sprache:eng
Schlagworte:
breast cancer
chemotherapy
interleukin-8
relative dose intensity
tumor necrosis factor-alpha
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Background Chemotherapy efcacy is largely dependent on treatment adherence, defned by the relative dose intensity (RDI). Identifcation of new modifable risk factors associated with low RDI might improve chemotherapy delivery. Here, we evaluated the association between low RDI and pre-chemotherapy factors, including patient- and treatment-related characteristics and markers of infammation. Methods This exploratory analysis assessed data from 267 patients with early-stage breast cancer scheduled to undergo (neo-)adjuvant chemotherapy included in the Physical training and Cancer (Phys-Can) trial. The association between low RDI, defned as