Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease

Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease

Background Serum selenium levels have been associated with the incidence of heart failure (HF) and signs of the metabolic syndrome. In addition, notable differences have been reported between males and females in food intake and micronutrient metabolism, possibly explaining different health outcomes...

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Hauptverfasser: Weening, Eerde H, Al-Mubarak, Ali A, Dokter, Martin M, Dickstein, Kenneth, Lang, Chim C, Ng, Leong L, Metra, Marco, van Veldhuisen, Dirk J, Touw, Daan J, de Boer, Rudolf A, Gansevoort, Ron T, Voors, Adriaan A, Bakker, Stephan J. L, van der Meer, Peter, Bomer, Nils
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Sprache:eng
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Zusammenfassung:Background Serum selenium levels have been associated with the incidence of heart failure (HF) and signs of the metabolic syndrome. In addition, notable differences have been reported between males and females in food intake and micronutrient metabolism, possibly explaining different health outcomes. Objective Our objective was to elucidate sex-specific, cross-sectional phenotypic differences in the association of serum selenium concentrations with parameters of metabolic syndrome and HF. Methods We investigated data from individuals from a community-based cohort (PREVEND; N = 4288) and heart failure cohort (BIOSTAT-CHF; N = 1994). In both populations, cross-sectional analyses were performed for potential interaction (p