Chronic fatigue syndrome (CFS): Suggestions for a nutritional treatment in the therapeutic approach

Chronic fatigue syndrome (CFS) is known as a multi-systemic and complex illness, which induces fatigue andlong-term disability in educational, occupational, social, or personal activities. The diagnosis of this disease isdifficult, due to lacking a proper and suited diagnostic laboratory test, besides to its multifaceted symptoms.Numerous factors, including environmental and immunological issues, and a large spectrum of CFS symptoms,have recently been reported. In this review, we focus on the nutritional intervention in CFS, discussing the manyimmunological, environmental, and nutritional aspects currently investigated about this disease. Changes inimmunoglobulin levels, cytokine profiles and B- and T- cell phenotype and declined cytotoxicity of natural killercells, are commonly reported features of immune dysregulation in CFS. Also, some nutrient deficiencies (vitaminC, vitamin B complex, sodium, magnesium, zinc, folic acid,L-carnitine,L-tryptophan, essential fatty acids, andcoenzyme Q10) appear to be important in the severity and exacerbation of CFS symptoms. This review highlightsa far-driven analysis of mineral and vitamin deficiencies among CFS patients